腺样囊性癌动物模型的研究进展

Research progress on animal models of adenoid cystic carcinoma

二维码有效期 120s

摘要腺样囊性癌(ACC)是头颈部常见的恶性肿瘤，具有较高的神经侵袭率、局部复发率和远处转移率，预后较差。动物模型是研究肿瘤发病机制和有效药物的理想模型，本文总结了国内外近些年来头颈部涎腺和泪腺ACC动物模型的建立方法和优缺点，为合理选择和优化动物模型奠定基础。

abstractsAdenoid cystic carcinoma (ACC) is a common malignant tumor in the head and neck, with a high rate of neuroinvasion, local recurrence, and distant metastasis, and a poor prognosis. Animal models are ideal models for studying the pathogenesis of tumors and effective drugs. This article summarizes the methods and advantages and disadvantages of establishing animal models for head and neck salivary and lacrimal gland ACC in recent years, laying a foundation for the rational selection and optimization of animal models.

作者柳睿 ^[1] 马建民 ^[1] 学术成果认领

作者单位首都医科大学附属北京同仁医院　北京同仁眼科中心　北京市眼视光与视觉科学重点实验室，北京　100730 ^[1]

关键词癌，腺样囊性涎腺泪腺模型，动物 Carcinoma, adenoid cystic Salivary glands Lacrimal gland Models, animal

栏目名称综述

DOI 10.3760/cma.j.cn431274-20230726-00049

发布时间 2025-02-25

基金项目

北京市自然科学基金 北京市科技新星计划交叉合作课题 北京市医院管理中心"登峰"计划 Natural Science Foundation of Beijing Beijing Science and Technology Rising Star Program-Cross-cooperation Beijing Hospitals Authority′ Ascent Plan