摘要目的 评价Cockcroft-Gauh(CG)方程及肾脏疾病膳食改良试验(MDRD)方程计算的肾小球滤过率(GFR)在慢性肾小球肾炎患者的适用性.方法 选择2005年1月至2007年12月在中山大学附属第三医院肾内科就诊的慢性肾小球肾炎患者143例,用CG方程、MDRD1方程和简化MDRD方程,分别计算GFR值与99Tcm-DTPA检测的GFR(sGFR)进行比较.结果 Bland-Altman分析显示CG方程估计的GFR和sGFR的一致性较好,但所有各方程估计的GFR和sGFR的一致性限度均超过事先规定的专业界值.线性回归结果 显示,CG方程估测的GFR与x轴的斜率较其他方程更接近0.从总体以及慢性肾脏病(CKD)的不同分期分析,CG方程较其他方程有较小的偏差和更优的准确性.结论对于慢性肾小球肾炎患者肾功能的评估,当血肌酐的测定方法 为酶法时,CG方程优于MDRD1方程和简化MDRD方程.

abstractsObjective To evaluate the applicability of glomerular filtration rate (GFR) caJcuated by Cock-croft-Gault equation, MDRD1 equation and abbreviated MDRD equation in the chronic glomerulonephritis. Methods 143 chronic kidney disease(CKD) patients diagnosed in our hospital from January 2005 to December 2007 were investigated. Glomerular filtration rate(GFR) was estimated with Cockcroft-Gault equation, MDRD1 equation and ab-breviated MDRD equation. The accuracy of estimated GFRs was compared with 99Tcm-DTPA-GFR in chronic glomer-ulonephritis patients. Results Bland-Altman analysis demonstrated that Cockcroft-Gault equation was more consist-ent with GFR and sGFR than the other equations. Linear regression analysis showed that the slopes of Cockcroft-Gault equation were closer to the identical line,with a smaller bias and higher accuracy . When compared, the bias as well as accuracy of estimated GFRs with sGFR in different stages of CKD,Cockcroft-Gault equation showed good results. Condusion When plasma creatinine is checked with enzymatic method, Cockcroft-Gault equation is more appropriate than MDRD1 equation and abbreviated MDRD equation for estimating renal function in chronic glomeru-lonephritis patients.