摘要目的 探讨初发糖尿病病患者胰岛B细胞早期分泌功能变化与最大体重下降的关系.方法 初发糖尿痛患者237例,按照最大体重下降幅度随机分组为1 kg以下组、1～5 kg组、5 kg以上组.治疗前记录前期最大体重及腰围,目前体重及腰围,行标准OGTT试验,同时测空腹和餐后30 min血糖、胰岛素及C-肽水平和血压等.并计算胰岛素抵抗指数(HOMA-IR)、早期胰岛素分泌指数(△I30/△G30)的变化.应用胰岛素泵强化治疗14 d后,复查上述各项指标.结果 B细胞早期分泌时相在体重减轻5 kg以上组恢复最差,1 kg以下组治疗后胰岛素分泌量较1～5 kg组和5 kg以上组分别增加1.12倍和1.86倍.结论 初发糖尿病最大体重下降幅度与胰岛素强化治疗前后B细胞早期分泌功能和恢复程度相关.

abstractsObjective To explore the relation of early time secretion function of Beta cell in newly diag-nosed type 2 diabetic patient and the changes of body weight following intensification therapy of insulin. Methods 237 newly diagnosed type 2 diabetic patients were divided into 1 kg lower group, the 1-5 kg group, the 5 kg above group. The maximum body weight and waist circumference were recorded. The present body weight and waist circum-ference were measured according to OGTT study, meanwhile,30 minuets blood sugars, the insulin and the C-peptide (C-P) level and the blood pressure(BP) and the insulin resistance index (HOMA-IR), the early insulin secretion index (△I30/△G30) was calculated. All cases were treated for 14 days. Results Early time secretion function of Beta cell in the group keeping above lose weight 5 kg was the worst, after treatment insulin secretion level were in-creased 1.12 times and 1.86 times in 1 kg lower group than in the 1-5 kg group and above 5 kg group. Conclusions Early time secretion function of Beta cell in newly diagnosed type 2 diabetic patient is correlated with the maxi-mum body weight decrease.