摘要目的 探讨含左氧氟沙星的10 d序贯疗法根除幽门螺杆菌(HP)的疗效.方法 将胃镜检查确诊为慢性胃炎和消化性溃疡伴HP阳性的86例患者采用随机数字表法分为两组,每组43例.治疗组前5d给予埃索美拉唑20 ng+阿莫西林1000 mg,2次/d,后5d给予埃索美拉唑20rg2次/d+左氧氟沙星500 mg 1次/d+呋喃唑酮100 mg2次/d；对照组三联疗法为埃索美拉唑20 mg+阿莫西林1000mg+克拉霉素500 mg,2次/d,疗程7d.用药方法均为口服,比较治疗后两组患者的HP根除率.结果 治疗组HP根除率为93.0％ (40/43),对照组为74.4％( 32/43),两组HP根除率差异有统计学意义(x2 =4.18,P＜0.05).结论 含左氧氟沙星的10 d序贯疗法治疗HP感染具有较高的根除率.

abstractsObjective To observe the efficacy of a Levofloxacin-containing 10-day sequential therapy for Helicobacter pylori eradication.Methods Totally 86 Helicobacter pylori-infected patients with chronic gastritis or peptic ulcer diagnosed by gastroscopy were randomized into two groups: the trial group and the control group (n =43 in each group).The trial group was treated with Esomeprazole 20 mg bid plus Amoxicillin 1000 mg bid at the first 5 days,and followed by Esomeprazole 20 mg bid,Levofloxacin 500 mg qd and Furazolidone 100 mg bid,at the last 5 days;The control group was treated with standard triple regimen: Esomeprazole 20 mg,Amoxicillin 1000 mg and Clarithromycin 500 mg,all bid for 7 days.The eradication rates of Helicobacter pylori in the two groups were compared after completion of treatment.Results After treatment,the eradication rates of Helicobacter pylori were significantly different between the trial and control group(93.0％ vs 74.4％,P ＜0.05)Conclusion The 10-day sequential therapy with.Levofloxacin-containing regime can achieve a higher eradication rate of Helicobacter pylori infection.