摘要目的 探讨诱发排卵障碍的多囊卵巢综合征(PCOS)患者血清甲状腺激素水平的变化及临床意义.方法 应用排卵药物(CC/HCG)诱发PCOS患者(89例)进行排卵,在诱发排卵的月经周期中,根据卵泡生长大小及是否成功排卵分为两组,排卵成功组49例、排卵障碍组40例,检测卵泡生长不同时期的血清甲状腺激素浓度,并进行统计学处理和分析.结果 卵泡生长至5、10、15 mm时,排卵障碍组与排卵成功组甲状腺激素水平差异均无统计学意义(P均＞0.05),卵泡生长至20 mm时[F组间分别为(4.38、50.34、48.65) P组间均＜0.05],T3、T4、TSH水平差异均有统计学意义,排卵成功组T3、T4水平高于障碍组[T3:(2.69±0.15) nmol/L与(1.97±0.17) nmol/L,T4:(124.38±0.29) nmol/L与(97.43±0.16) nmol/L],排卵成功组TSH水平低于障碍组[TSH:(1.38±0.18) mU/L与(3.43±0.10) mU/L] (P均＜0.05).结论 排卵成功组患者的甲状腺激素水平在卵泡成熟时处于正常水平,甲状腺激素水平低下可影响PCOS患者的正常排卵.

abstractsObjective To analyze the relationship and significance between plasma level of thyroid hormone and ovulation disorder of (polycystic ovary syndrome)PCOS.Methods Eighty-nine cases with PCOS were induced ovulation by CC+HCG.During menstrual cycle of induced ovulation,PCOS patients were divided into two groups according to Ovulation (No ovulation 40,ovulation 49).The level of thyroid hormone at different follicular development period and ovulatory time were detected.Result Levels of thyroid hormone at two groups were no difference at 5 mm,10 mm,15 mm size follicular phase(P＞0.05).But there was significant at follicular 20mm size(F inner groups=4.38,50.34,48.65;P＜0.05).The level of T3 an T4 at No ovulation group was lower than those in ovulation group(T3:(2.69±0.15) nmol/L vs.(1.97±0.17) nmol/L;T4:(124.38±0.29) nmol/L vs.(97.43±0.16) nmol/L).The level of TSH at No ovulation group was (3.43±0.10) mU/L,higher than that in ovulation group ((1.38 ± 0.18) mU/L;P ＜ 0.05).Conclusion The level of thyroid hormone in patients of ovulation group is at a normal level when the follicle is mature,and the level of thyroid hormone can affect the normal ovulation of patients with PCOS.