摘要目的 探讨美金刚联合盐酸多奈哌齐对阿尔茨海默病患者认知精神症状的影响.方法 将70例老年阿尔茨海默病患者应用计算机随机分为两组,美金刚联合盐酸多奈哌齐组(观察组)35例,奥氮平联合盐酸多奈哌齐组(对照组)35例,于治疗前和治疗6、12周应用罗萨阿尔茨海默病相关结果评分(ROSA)及神经精神问卷(NPI)评估表以及蒙特利尔认知评估量表(MoCA量表)进行评估.结果 观察组与对照组ROSA总分治疗前分别为(75.14±17.20)分与(73.97±17.29)分,治疗6周分别为(89.77±17.14)分与(80.84±15.31)分,治疗12周分别为(100.30±14.47)分与(89.31±13.30)分,两组治疗前比较差异无统计学意义(P＞0.05),治疗6、12周组间比较差异均有统计学意义(P均＜0.05);MoCA、NPI和NPI看护苦恼组间不同时间比较差异均无统计学意义(P均＞0.05).结论 美金刚与盐酸多奈哌齐联合治疗对阿尔茨海默病患者改善认知、交流、功能以及精神症状的疗效优于奥氮平联合盐酸多奈哌齐.

abstractsObjective To investigate the therapeutic effect of combination of memantine and donepezil on cognitive mental symptoms in patients with Alzheimer's disease.Methods Seventy cases elderly patients with Alzheimer's disease were randomly divided into two groups,memantine and donepezil group(treatment group)with 35 cases,donepezil hydrochloride and olanzapine group(control group)with 35 cases.Scoring in before treatment and 6,12 weeks after treatment in application of rosa linked to Alzheimer's disease(ROSA)and the neuropsychiatric Inventory(NPI)assessment,montreal cognitive assessment scale(MoCA scale)were assessed.Results ROSA scores in before treatment and 6,12 weeks after treatment of treatment group and control group was(75.14±17.20)points and(73.97±17.29)points,(89.77±17.14)points and(80.84±15.31)points,(100.30±14.47)points and(89.31±13.30)points,there were statistically significant differences before treatment between the two groups(P＜0.05),there were statistically significant differences 6,12 weeks after treatment inner groups(P＜0.05).MoCA,NPI and NPI care distress comparison between groups differences were not statistically significant(P＞0.05).Conclusion The combined treatment of memantine and donepezil in Alzheimer's disease can improve cognitive function and mental symptoms,communication,etc.The effect of agitation or attack than the control group is significantly different.