摘要目的 探讨骨化三醇联合坤泰胶囊在多囊卵巢综合征患者中的应用效果.方法 选取我院97例多囊卵巢综合征患者,随机分为两组,对照组48例给予枸橼酸氯米芬胶囊治疗,观察组49例在以上基础上加用骨化三醇联合坤泰胶囊治疗.观察比较两组治疗效果、诱排日子宫内膜厚度、成熟卵泡个数、宫颈黏液评分及用药前后性激素各指标[黄体生成素(LH)、雄性激素睾酮(T)、卵泡刺激素(FSH)、雌二醇(E2)]、血清单核细胞趋化因子1(MCP-1)、瘦素(Leptin )水平变化情况,并统计两组妊娠率及不良反应发生率.结果 观察组治疗总有效率为95. 92%(47/49),高于对照组79. 17%(38/48),差异有统计学意义(χ2＝6. 277,P＝0. 012);观察组诱排日子宫内膜厚度、成熟卵泡个数及宫颈黏液评分均大于对照组,差异均有统计学意义(t值分别为4. 978、7. 175、7. 387,P均＜0. 05);用药3个月后观察组血清T、FSH、LH及MCP-1、Leptin 水平均低于对照组,血清E2水平高于对照组,差异均有统计学意义( P均＜0. 05);观察组妊娠率为69. 39%(34/49),高于对照组47. 92%(23/48),差异有统计学意义(χ2＝4. 613, P＝0. 032);观察组不良反应发生率为12. 24%(6/49),对照组为8. 33%(4/48),组间比较差异无统计学意义(χ2＝0. 090,P＝0. 765).结论 骨化三醇联合坤泰胶囊治疗可改善多囊卵巢综合征患者血清MCP-1、Leptin 水平及性激素水平,提高妊娠率,效果显著,且用药安全性高.

abstractsObjective To investigate the application effect of calcitriol combined with Kuntai capsule in patients with polycystic ovary syndrome. Methods Ninety-seven cases with polycystic ovary syndrome were enrolled in the study and were randomly divided into two groups, 48 cases in the control group were given clomifene citrate capsules, and 49 cases in the observation group were treated with calcitriol combined with Kuntai capsule on the basis of the control group. The treatment effect,endometrial thickness,number of mature follicles,cervical mucus score and sex hormones (luteinizing hormone (LH),androgen,testosterone (T),follicle stimulating hormone (FSH),estradiol (E2)) before and after the treatment,the serum monocyte chemotactic factor -1 (MCP-1) and Leptin level of the two groups were observed and compared. And the rate of pregnancy and the incidence of adverse reactions were recorded. Results The total efficiency of the observation group was 95.92%(47/49),higher than that of the control group (79.17%(38/48))(χ2 ＝6.277,P＝0.012).The endometrial thickness,the number of mature follicles and the cervical mucus score of the observation group were significantly higher than those of the control group(t＝4. 978,7. 175,7. 387,P＜0. 05). After 3 months,the serum levels of T,FSH,LH,MCP-1 and Leptin in the observation group were lower than those in the control group,and the serum E2 level was higher than in the control group(P＜0. 05). The pregnancy rate of the observation group the was 69. 39%( 34/49 ), higher than that of the control group ( 47. 92%( 23/48 )), the difference was statistically significant (χ2＝4. 613,P＝0. 032). The incidence of adverse reactions was 12. 24%(6/49) in the observation group and 8. 33%(4/48) in the control group. There was no significant difference between the two groups(P＞0. 05). Conclusion Calcitriol combined with Kuntai capsule can improve the serum MCP-1,Leptin levels and sex hormone levels in patients with polycystic ovary syndrome,and improve the prognosis of pregnancy rate. Besides,the effect is remarkable with high medication safety.