摘要TIn the human gastrointestinal tract, the functional mucosa of the small intestine has the highest capacity for absorption of nutrientsand rapid proliferation rates, making it vulnerable to chemoradiotherapy. Recent understanding of the protective role of p53-mediated cell cycle arrest in the small intestinal mucosa has led researchers to explore new avenues to mitigate mucosal injury duringcancer treatment. A traditional p53 inhibitor and two other molecules that exhibit strong protective eff ects on normal small intestinalepithelium during anticancer drug treatment and radiation therapy are introduced in this work. The objective of this review was toupdate current knowledge regarding potential mechanisms and targets that inhibit the side eff ects induced by chemoradiotherapy.