Liquid biopsies for liquid tumors：emerging potential of circulating free nucleic acid evaluation for the management of hematologic malignancies

二维码有效期 120s

摘要Circulating free nucleic acids; cell free DNA and circulating micro-RNA, are found in the plasma of patients with hematologic and solid malignancies at levels higher than that of healthy individuals. In patients with hematologic malignancy cell free DNA reflects the underlying tumor mutational profile, whilst micro-RNAs reflect genetic interference mechanisms within a tumor and potentially the surrounding microenvironment and immune effector cells. These circulating nucleic acids offer a potentially simple, non-invasive, repeatable analysis that can aid in diagnosis, prognosis and therapeutic decisions in cancer treatment.

作者单位 Myeloma Research Group, Australian Center for Blood Diseases, Monash University, Melbourne 3004, Australia ^[1] Malignant Haematology & Stem Cell Transplantation Service, Alfred Hospital, Melbourne 3004, Australia ^[2]

关键词 Circulating nucleic acids DNA miRNA hematologic malignancy biopsy

DOI 10.20892/j.issn.2095-3941.2016.0025

发布时间 2016-07-06

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交