Technical advances in NK cell-based cellular immunotherapy

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摘要Natural killer (NK) cells represent a promising future for tumor immunotherapy because of their unique biological functions and characteristics. This review focuses on technical advances in NK cell-based cellular immunotherapy and summarizes the developments of recent years in cell sources, genetic modification, manufacturing systems, clinical programs, and outcomes. Future prospects and challenges in NK cell immunotherapy are also discussed, including off-the-shelf NK cell exploitation, automatic and closed manufacturing systems, cryopreservation, and therapies involving regulatory checkpoints.

作者单位 Department of Oncology of The First Affiliated Hospital, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China;Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China;Institute of Immunology, University of Science and Technology of China, Hefei 230027, China;Engineering Technology Research Center of Biotechnology Drugs Anhui, University of Science and Technology of China, Hefei 230027, China ^[1] Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China;Institute of Immunology, University of Science and Technology of China, Hefei 230027, China;Engineering Technology Research Center of Biotechnology Drugs Anhui, University of Science and Technology of China, Hefei 230027, China ^[2]

关键词 Natural killer cell immunotherapy adoptive cell transfer genetic modification

栏目名称

REVIEW

DOI 10.20892/j.issn.2095-3941.2019.0187

发布时间 2020-04-09

基金项目

grants from the Chinese Academy of Sciences（Grant XDB29030201, XBD29030202）； the Ministry of Science and Technology of China（Grant 2016YFC1303503）； the National Natural Science Foundation of China（Grant 81788101, 81671558, 31571440, 81821001, 91542000）； Major Projects of Science and Technology in Anhui Province（Grant 17030801024）； the Fundamental Research Funds for the Central Universities（Grant YD2070002004）

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