COVID-19 in cancer patients: risk, clinical features, and management

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摘要A novel coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread across the world, prompting the World Health Organization to declare the coronavirus disease of 2019 (COVID-19) a public health emergency of international concern. Cancer patients are regarded as a highly vulnerable population to SARS-CoV-2 infection and development of more severe COVID-19 symptoms, which is possibly due to the systemic immunosuppressive state caused directly by tumor growth and indirectly by effects of anticancer treatment. Currently, much effort has been directed toward studying the pathogenesis and treatment of COVID-19, but the risk profiles, prognoses, and treatment outcomes in cancer patients remain unclear. Based on the current literature, we summarize the risk profiles, clinical and biochemical characteristics, and therapy outcomes of COVID-19 infections in cancer patients. The challenges in the clinical care of cancer patients with COVID-19 are discussed. The goal of this review is to stimulate research to better understand the biological impact and prognoses of COVID-19 infections in cancer patients, thus facilitating improvement of the clinical management of these patients.

作者 Cuiwei Liu ^[1] Yanxia Zhao ^[2] Derick Okwan-Duodu ^[3] Reva Basho ^[4] Xiaojiang Cui ^[5] 学术成果认领

作者单位 Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China;Department of Surgery, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA ^[1] Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China ^[2] Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA;Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA ^[3] Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA ^[4] Department of Surgery, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA ^[5]

关键词 Anti-viral therapy anti-cancer treatment COVID-19 immunotherapy inflammation SARS-CoV-2

栏目名称 REVIEW

DOI 10.20892/j.issn.2095-3941.2020.0289

发布时间 2020-09-25

基金项目

We thank Margarita Castillon for proofreading the manu-script. Xiaojiang Cui is supported by the National Institutes of Health

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