摘要Ferroptosis, a type of regulated cell death named one dec-ade ago, is a unique type driven by lipid peroxidation in an iron-dependent manner. Ferroptosis differs radically from apoptosis and other regulated forms of cell death in both morphology and molecular underpinning. Ferroptosis can be triggered by a variety of physiologic conditions and patho-logic stresses. There has been growing interest in ferroptosis in recent years, and research on ferroptosis is productive. The existing evidence has shown that ferroptosis is closely related to cancer initiation, progression, and suppression. Thus, fer-roptosis has shown promising potential in cancer therapies. Inducing ferroptosis in tumors and the combination of fer-roptosis inducers with other therapies may overcome drug resistance during cancer treatment. Because of the intricate network regulating ferroptosis-related pathways, drugs tar-geting ferroptosis are diverse and complicated. Thus, deci-phering the complexity of ferroptosis and precisely targeting ferroptosis are needed.