摘要Objective:The burden of gastric cancer(GC)across different age groups needs updating.We determined the GC global,regional,and national burden profiles and changes in incidence for 3 sequential 5-year intervals from 2003 to 2017.Methods:The latest incidence and mortality estimates of GC from 185 countries and regions were extracted from the GLOBOCAN 2022 database.The 5-year interval age-standardised incidence rates(ASIRs)were evaluated using cancer registry data from volumes Ⅹ-Ⅻ of the Cancer Incidence in Five Continents(CI5).Correlation analysis was used to evaluate the relationship between ASIR or the age-standardised mortality rate(ASMR)and the Human Development Index(HDI).Results:There was an estimated global 968,000 new GC cases and 660,000 deaths in 2022,with male predominance.GC ASIRs and ASMRs were 9.2 and 6.1 per 100,000 persons,respectively.East Asia had the highest burden,with 53.8％of cases and 48.2％of deaths among all geographic regions.There was a significant correlation between ASIR and HDI.Over three 5-year intervals from 2003 to 2017,the incidence of GC notably decreased in most countries but peaked at 2008-2012 in New Zealand,Turkey,and South Africa.Several countries in Europe,Oceania,and America suggest an increasingly concerning trend among younger individuals,especially females.Conclusions:GC is a significant health issue,especially among males and in geographic regions with an HDI,such as eastern Asia.While the incidence of GC is decreasing in many countries due to prevention efforts and improved treatments,a rising trend persists among younger individuals.Comprehensive prevention strategies tailored to different age patterns are clearly needed.