摘要Objective:To investigate the effect of traditional Chinese Five-body balance exercise on patients with preserved ratio impaired spirometry(PRISm).Methods:Fifteen patients with PRISm and 15 patients diagnosed with chronic obstructive pulmonary disease(COPD)were recruited from the Outpatient Department of Guang'anmen Hospital and Beijing Niujie Health Service Center from April to December,2023.Participants in both groups attended supervised Five-body balance exercise training twice a week for 12 weeks.Patients with COPD continued their regular medication regimen during the intervention period.The endpoints were mean changes in the 6-min walk test(6MWT),St.George's Respiratory Questionnaire(SGRQ)score,cardiopulmonary exercise testing(CPET),pulmonary function,and scores of COPD assessment test(CAT),modified British Medical Research Council,Self-Rating Anxiety Scale,and Self-Rating Depression Scale from baseline to 12 weeks.Adverse events were monitored throughout the study.Results:The PRISm group showed a significant improvement from baseline to week 12 in 6MWT,SGRQ symptom score,and forced vital capacity(FVC)compared to the COPD group(P＜0.05).No significant between-group changes were observed in other outcome measurements(P＞0.05).In addition,compared with baseline,both groups exhibited improvements in 6MWT,SGRQ score,and CPET at week 12(P＜0.05).The PRISm group also showed a significant increase in forced expiratory volume in 1 s and FVC,as well as a significant decrease in CAT score at week 12(P＜0.05).No adverse events were reported.Conclusion:Patients with PRISm may benefit from Five-body balance exercise training,which can improve the exercise capacity,health-related quality of life,and lung function.(Registration No.ChiCTR2200059290)