摘要目的：探讨胎盘绒毛膜血管瘤的临床病理特点、诊断及鉴别诊断。方法回顾性分析25例胎盘绒毛膜血管瘤的临床病理资料、大体及镜下形态学特点，采用免疫组织化学方法检测肿瘤组织CD34及Ki-67的表达情况。结果25例患者平均年龄29岁，足月产14例，早产10例，胎死宫内1例，19例有妊娠合并症。肿瘤大体表现为凸出于胎盘胎儿面的暗红色、界限较清的结节，直径1～16 cm，切面暗红色，部分可为海绵状血管腔，镜下通常表现为小而密集的毛细血管，部分为扩张的海绵状血管，极少数富于细胞，免疫组织化学染色表达CD34，Ki-67阳性指数＜10％。结论胎盘绒毛膜血管瘤较少见，极少数富于细胞性，易被误诊为恶性，常伴发多种妊娠合并症。

abstractsObjective To investigate the clinicopathological characteristics , diagnostic criteria and differential diagnosis of placental chorioangioma.Methods Twenty-five cases of placental chorioangioma were analyzed for their clinical data , histomorphology and immumohistochemical staining .Relevant literature was reviewed.Results The average age of the 25 patients was 29 years.Fourteen patients had full-term pregnancy , 10 had preterm labor , and 1 had intrauterine fetal death .Nineteen patients had pregnancy complications.The tumors presented as red or dusty pink nodules with clear borders.The tumor size ranged from 1 to 16 cm.Microscopically , the tumors possessed abundant capillaries or cavernous blood spaces lined by hyperplastic endothelial cells.These cells were positive for CD 34 and Ki-67 index <10%.Conclusions Placental chorioangioma is a rare benign tumor of the placenta , and is associated with various pregnancy complications .Misdiagnosis of cell-rich type tumor should be avoided .