摘要This paper reports 715 cases of primary cutaneous amyloidosis, among which are 33 rare poikiloderma-like cutaneous amyloidosis and 71 new seborrheic dermatitis-like cutaneous amyloidosis. The characteristics of early lesions and the regularity of their occurrence and development are noted. The types described in the literature may only be different developmental stages of the ordinary type. The newly demonstrated 4-5 paralell yellowish band-like lesions over the lower back need further study. There are protein abnormalities and blood lipids, especially triglycerides are increased. The neutral fat in the amyloid deposits is proved by histochemical staining. The increase in triglycerides and skin specimen fatty acid content is shown by infrared spectrophotometry and neutral fat thin layer chromatography. These suggest that metabolic disturbance of lipids and proteins may have something to do with the pathogenesis of the disease. Family history shows autosomal dominant inheritance with higher but incomplete penetrance in the ordinary type and autosomal recessive inheritance in the PCA type.
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