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PRIMARY CUTANEOUS AMYLOIDOSIS

摘要This paper reports 715 cases of primary cutaneous amyloidosis, among which are 33 rare poikiloderma-like cutaneous amyloidosis and 71 new seborrheic dermatitis-like cutaneous amyloidosis. The characteristics of early lesions and the regularity of their occurrence and development are noted. The types described in the literature may only be different developmental stages of the ordinary type. The newly demonstrated 4-5 paralell yellowish band-like lesions over the lower back need further study. There are protein abnormalities and blood lipids, especially triglycerides are increased. The neutral fat in the amyloid deposits is proved by histochemical staining. The increase in triglycerides and skin specimen fatty acid content is shown by infrared spectrophotometry and neutral fat thin layer chromatography. These suggest that metabolic disturbance of lipids and proteins may have something to do with the pathogenesis of the disease. Family history shows autosomal dominant inheritance with higher but incomplete penetrance in the ordinary type and autosomal recessive inheritance in the PCA type.

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作者 Qiu Bing—sen [1] Li Zu-xi [1] Li Chang-heng [1] Liao Kang-huang [2] Kang Ke-fei [3] Shi Shou-yi [3] Chen Hong-ji [4] Li Wen-jing [4] Wang Gen-sheng [5] Yang Kuo-liang 学术成果认领
作者单位 Department of Pathology, Huashan Hospital, Shanghai First Medical College [1] Department of Biochemistry, Huashan Hospital, Shanghai First Medical College [2] Department of Immunology, Institute of Dermatology, Huashan Hospital, Shanghai First Medical College [3] Laboratory of Internal Medicine, Huashan Hospital, Shanghai First Medical College [4] 5th Department, Institute of Organic Chemistry, Academia Sinica [5]
发布时间 2020-04-28
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CHINESE MEDICAL JOURNAL

CHINESE MEDICAL JOURNAL

1983年96卷3期

185-200页

SCIMEDLINEISTICCSCDCABP

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