ASPIRIN AND DIPYRIDAMOLE INHIBITION OF COLLAGEN-INDUCED PLATELET AGGREGATION AND RELEASE IN CYNOMOLGUS MONKEYS

二维码有效期 120s

摘要The in vitro aggregability of platelets and release of platelet granular material were studied in platelets isolated from cynomolgus monkeys (Macaca fascicularis) as related to oral medication with aspirin and dipyridamole. In treated monkeys platelet aggregation decreased in response to low but not high collagen concentrations. Release of platelet serotonin reduced in treated animals at all collagen concentrations but this reduction was more pronounced at low collagen concentrations. The effectiveness of aspirin and dipyridamole in preventing platelet aggregation and release reaction at sites of vascular injury may therefore depend on the amount of exposed subendothelial collagen.

作者 Wang Zhong-gao ^[1] Richard L McCann ^[2] Per-Otto Hagen ^[2] 学术成果认领

作者单位 Department of Surgery, Capital Hospital, Chinese Academy of Medical Sciences, Beijing ^[1] Department of Surgery, Atherosclerosis Research Laboratory, Duke University Medical Center, USA ^[2]

主题词阿司匹林(Aspirin)双嘧达莫(Dipyridamole)血小板聚集(Platelet Aggregation)成束猴(Macaca fascicularis)抑制(心理学)(Inhibition (Psychology))

发布时间 2020-04-28