Demonstration of the anti-viral activity of garlic extract against human cytomegalovirus in vitro

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摘要The in vitro anti-viral activity of garlic extract (GE) on human cytomegalovirus (HCMV) was evaluated by tissue culture, plaque reduction and early antigen assay. A dose dependent inhibitory effect of GE was evident when GE was applied simultaneously with HCMV. But the effect was stronger when the monolayers were pretreated with GE. In addition, the anti-viral effect of GE persisted long in infected cells after its being removed from the culture medium. The strongest anti-viral effect of GE was demonstrated when it was applied continuously. It is therefore recommended that clinical use of GE against HCMV infection should be persistent and the prophylactic use of GE is preferable in immunocompromised patients.

作者 Guo Nai-lan ^[1] Lu Dao-pei ^[1] Gail L. Woods ^[2] Elizabeth Reed ^[1] Zhou Gui-zhen ^[3] Zhang Li-bi ^[3] Robert H. Waldman ^[2] 学术成果认领

作者单位 Institute of Hematology, Beijing Medical University, Beijing 100044 ^[1] University of Nebraska Medical Center, USA ^[2] Institute of Virology, Chinese Academy of Preventive Medicine, Beijing ^[3]

主题词大蒜(Garlic)人类(Humans)巨细胞病毒(Cytomegalovirus)体外研究(In Vitro)文化(Culture)

栏目名称 Original Article

发布时间 2020-04-28