Effects of pinacidil on proliferation of cultured rabbit airway smooth muscle cells induced by endothelin-1

二维码有效期 120s

摘要篇首： It has been found that the potassium channel dysfunction of the membrane of airway smooth muscle cells (ASMCs) is closely associated with proliferation of ASMCs.1 Preliminary research has demonstrated that pinacidil, an ATP sensitive potassium channel (KATP) opener, could play a remarkable role in the prevention and treatment of antigen induced bronchial asthma in guinea pigs.2 This study was designed to investigate further the role and molecular mechanism of the proliferation of ASMCs: a chief pathological change of the nonacute phase of bronchial asthmatic episodes.

作者单位 Department of Respiratory Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ^[1]

关键词 airway smooth muscle cells proliferation pinacidil endothelin-1

分类号 R3

栏目名称 BRIEF REPORTS

发布时间 2005-07-07

基金项目

the State Key Project of New Drug Research and Development 国家自然科学基金 Jiangsu Committee of Science and Technology the Research Fund from Education Committee of Jiangsu Province

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