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换一批Direct, real-time PCR (MethyLight) assay for methylation of O6-methylguanine-DNA methyltransferase promoter in glioma
摘要篇首： O6-Methylguanine-DNA methyltransferase (MGMT) is a cellular DNA repair protein that rapidly reverses alkylation (e.g. methylation) at the O6 position of guanine,thereby neutralizing the cytotoxic effects of alkylating agent therapy such as temozolomide (TMZ) and carmustine.1It has been shown that epigenetic silencing of the MGMT gene by promoter methylation shuts down gene transcription2 and reflects a common alteration in primary human tumors leading to MGMT deficiency)Epigenetic silencing of the MGMT gene has been shown to correlate with improved survival in several studies of glioma" patients treated with the alkylating agent. 56therapy4 and has been substantiated in two clinical trials.5.6
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关键词
06-methylguanine-DNA-methyltransferasereal-time PCRmethylation-specific PCRgliomadrug resistance
分类号
R5
栏目名称
BRIEF REPORT
DOI
10.3760/cma.j.issn.0366-6999.2009.11.019
发布时间
2009-06-30
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- 被引4
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