摘要Background Lovastatin is an effective drug for treatment of hyperlipidemia.This study aimed to clone Iovastatin biosynthesis regulatory gene lovE and analyze the structure and function of its encoding protein.Methods According to the Iovastatin synthase gene sequence from genebank,primers were designed to amplify and clone the Iovastatin biosynthesis regulatory gene lovE from Aspergillus terms genomic DNA.Bioinformatic analysis of lovE and its encoding animo acid sequence was performed through intemet resources and software like DNAMAN.Results Target fragment lovE,almost 1500 bp in length,was amplified from Aspergillus terms genomic DNA and the secondary and three-dimensional structures of LovE protein were predicted.Conclusion In the Iovastatin biosynthesis process lovE is a regulatory gene and LovE protein is a GAL4-1ike transcriptional factor.