换一批
换一批Febuxostat, a nonpurine selective inhibitor of xanthine oxidase: a promising medical therapy for chronic heart failure?
摘要篇首： Heart failure is currently one of the most common and most cost-intensive of the chronic diseases.1 The main cause of chronic heart failure (CHF) is the abnormalities of both cardiac contractile performance and myocardial energy metabolism. Elevated levels of reactive oxygen species (ROS) have been proposed to contribute to both of them. Xanthine oxidoreductase (XO)is a major source of ROS in the cardiovascular system.
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关键词
febuxostatreactive oxygen speciesxanthine oxidase inhibitorschronic heart failuresignaling pathways
分类号
R5
DOI
10.3760/cma.j.issn.0366-6999.2010.17.033
发布时间
2010-10-12
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