摘要Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in adults.The renal biopsy is the gold standard for the disease diagnosis,but is invasive.M-type phospholipase A2 receptor (PLA2R) on human podocytes could serve as the target for podocytopathic antibodies (anti-PLA2R).1 Patients with iMN (70%-80%) were found the circulating antibodies against PLA2R.1 And the podocyte-secreted angiopoietinlike-4 (Angptl4) could be another key role in nephrotic syndrome3.
作者单位Kidney Disease Center, the First Affiliated Hospital, Zhejiang University College of Medicine; Kidney Disease Immunology Laboratory, The Third Grade Laboratory, State Administration of Traditional Chinese Medicine of China; Key Laboratory of Multiple Organ Transplantation, Ministry of Health of China; Key Laboratory of Nephropathy, Zhejiang Province, Hangzhou, Zhejiang 310003, China[1]