摘要Background Type Ⅱ diabetes mellitus usually related to visceral and other organ (ectopic) fat.The purpose of this study was to detect hepatic and pancreatic fat infiltration in type Ⅱ diabetes mellitus patients using 3.0T magnetic resonance (MR) and to compare the performance of iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL-Quant)with single-voxel proton spectroscopy (H1-MRS).Methods The study protocol was approved by our Institutional Review Board.Written informed consent was obtained from each subject in this study.We prospectively performed IDEAL-Quant and single-voxel proton spectroscopy with an echo time of 35 ms on 24 type Ⅱ diabetes patients and 10 healthy volunteers.The hepatic proton density fat fraction (HPDFF) and pancreatic proton density fat fraction (PPDFF) were calculated,compared,and analyzed by t-tests and Spearman's correlation.Results The HPDFF and PPDFF measured with IDEAL-Quant were significantly different between the healthy volunteers and type Ⅱ diabetes patients (th=9.377,P=0.000; tp=2.813,P=0.008).The HPDFF and PPDFF measured with MRS were also significantly different between the healthy volunteers and type Ⅱ diabetes patients (th=5.342,P=0.000; tp=2.63,P=-0.013).The HPDFF and PPDFF measured by the two methods were in good agreement (rh=0.854,P=0.000; rp=0.774,P=-0.000).The HPDFF and PPDFF were not significantly correlated with each other (rMRS=0.203,p=0.248; rIDEAL-Quant=0.301,P=-0.084).The PPDFF measured with IDEAL-Quant was associated with body mass index (r=0.377,P=0.028).Conclusion IDEAL-Quant is a nice method for hepatic and pancreatic fat detection,and it can be applied in clinical practice.