摘要Background:Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is an effective technique used to precisely detect enlarged mediastinal lymph nodes.The efficacy of EBUS-TBNA versus standard modalities for the diagnosis ofsarcoidosis remains to be elucidated.In this meta-analysis,we compared the efficacies of these methods.Methods:We searched PubMed,Embase,The Cochrane Library,Wanfang,Cpvip,CNKI,and the bibliographies of the relevant references.We analyzed the data obtained with Revman 5.2 (Nordic Cochrane Center,Copenhagen,Denmark) and Stata 12.0 software (Stata Corporation,College Station,TX,USA).The Mantel-Haenszel method was used to calculate the pooled odds ratio (OR) and 95％confidence intervals (CIs).Results:Sixteen studies with a total of 1823 participants met the inclusion criteria,and data were extracted regarding the diagnostic yield of each approach.The ORs for EBUS-TBNA versus transbronchial lung biopsy (TBLB) for the diagnosis of sarcoidosis ranged from 0.26 to 126.58,and the pooled OR was 5.89 (95％ CI,2.20-15.79,P =0.0004).These findings indicated that EBUS-TBNA provided a much higher diagnostic yield than TBLB.The pooled OR for EBUS-TBNA + TBLB + endobronchial biopsy (EBB) versus TBNA + TBLB + EBB was 1.54 (95％ CI,0.61-3.93,P =0.36),implying that there was no significant difference between their diagnostic yields.However,clinical heterogeneity was reflected in the nature of the studies and in the operative variables.Conclusions:The results of this meta-analysis suggest that EBUS-TBNA + TBLB + EBB could be used for the diagnosis of sarcoidosis,if available.At medical centers without EBUS-TBNA,TBNA + TBLB + EBB could be used instead.