Postrandomization Confounding Challenges the Applicability of Randomized Clinical Trials in Comparative Effectiveness Research

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摘要WHAT IS THE PROBLEM?Different from trials for regulatory approvals of new interventions aimed to test the efficacy,comparative effectiveness research (CER) is the direct comparison of existing health-care interventions (compared with active controls) to examine which treatment works best,for whom,and under what settings.[1] Therefore,CER is indispensable to assist consumers,clinicians,purchasers,and policy makers to make evidence-based decisions.Actually,an obvious uprising tendency of CER after 2004 was displayed and a majority of CER was performed by randomized clinical trials (RCTs) with active controlled interventions.

作者单位 Center for Clinical Epidemiology and Evidence-based Medicine, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China ;Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing 100045, China ^[1] Center for Clinical Epidemiology and Evidence-based Medicine, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China ^[2] Center for Medical Safety and Risk Administration, National Institute of Hospital Administration, Beijing 100091, China ^[3]

关键词 Comparative Effectiveness Research Postrandomization Confounding Randomized Clinical Trials

栏目名称 Perspective

DOI 10.4103/0366-6999.204117

发布时间 2017-05-22

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