Virome in immunodeficiency: what we know currently

二维码有效期 120s

摘要Over the past few years, the human virome and its complex interactions with microbial communities and the immune system have gained recognition as a crucial factor in human health. Individuals with compromised immune function encounter distinctive challenges due to their heightened vulnerability to a diverse range of infectious diseases. This review aims to comprehensively explore and analyze the growing evidence regarding the role of the virome in immunocompromised disease status. By surveying the latest literature, we present a detailed overview of virome alterations observed in various immunodeficiency conditions. We then delve into the influence and mechanisms of these virome changes on the pathogenesis of specific diseases in immunocompromised individuals. Furthermore, this review explores the clinical relevance of virome studies in the context of immunodeficiency, highlighting the potential diagnostic and therapeutic gains from a better understanding of virome contributions to disease manifestations.

abstractsOver the past few years, the human virome and its complex interactions with microbial communities and the immune system have gained recognition as a crucial factor in human health. Individuals with compromised immune function encounter distinctive challenges due to their heightened vulnerability to a diverse range of infectious diseases. This review aims to comprehensively explore and analyze the growing evidence regarding the role of the virome in immunocompromised disease status. By surveying the latest literature, we present a detailed overview of virome alterations observed in various immunodeficiency conditions. We then delve into the influence and mechanisms of these virome changes on the pathogenesis of specific diseases in immunocompromised individuals. Furthermore, this review explores the clinical relevance of virome studies in the context of immunodeficiency, highlighting the potential diagnostic and therapeutic gains from a better understanding of virome contributions to disease manifestations.

作者 Wang Hu ^[1] Xu Siqi ^[2] Li Shuang ^[1] Su Bin ^[1] Sherrill-Mix Scott ^[3] Liang Guanxiang ^[2] 学术成果认领

作者单位 Beijing Key Laboratory for HIV/AIDS Research, Clinical and Research Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China ^[1] Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing 100084, China ^[2] Department of Microbiology amp; Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA ^[3]

关键词 Human virome Immunodeficiency People living with HIV PLWH Diagnosis Therapeutics Autoimmune diseases Organ transplantation Human virome Immunodeficiency People living with HIV PLWH Diagnosis Therapeutics Autoimmune diseases Organ transplantation

栏目名称 Review Article

DOI 10.1097/CM9.0000000000002899

发布时间 2025-02-25

基金项目

This work was supported by grants from the Start-up Foundation of Tsinghua University the Tsinghua-Peking Center for Life Sciences the National Key R&D Program of China the National Natural Science Foundation of China the Beijing Natural Science Foundation the High-Level Public Health Specialized Talents Project of Beijing Municipal Health Commission the Beijing Key Laboratory for HIV/AIDS Research