摘要目的:回顾性分析宁波地区健康人群血清丙氨酸转氨酶(ALT)的检测结果，重新评估ALT正常值上限(ULN)。方法:以2018年至2020年在宁波大学医学院附属医院和宁波鄞州华茂医院进行健康体格检查并接受肝脏生物化学指标检测的56 140名体格检查者为研究对象，排除可能导致肝损伤的因素后纳入11 411名受检者，比较不同性别和不同年龄(20~29岁、30~39岁、40~49岁、50~59岁)人群的血清ALT，确定不同性别人群的ALT ULN，统计学分析采用两独立样本 t检验和方差分析。 结果:男性血清ALT为(19.20±7.90) U/L，高于女性的(13.75±6.17) U/L，差异有统计学意义( t＝41.16， P<0.001)；男性血清ALT ULN为35 U/L，女性为26 U/L。20~29岁组、30~39岁组、40~49岁组、50~59岁组的血清ALT分别为(15.48±7.61) U/L、(16.21±7.40) U/L、(17.36±7.52) U/L、(18.77±7.57) U/L，差异有统计学意义( F＝71.51， P<0.001)。50~59岁组血清ALT高于20~29岁组，差异有统计学意义( t＝13.11， P<0.01)。男性中，20~29岁组ALT ULN最低，为34.43 U/L，40~49岁组ALT ULN最高，为35.29 U/L。女性中，20~29岁组ALT ULN最低，为23.01 U/L，50~59岁组ALT ULN最高，为30.79 U/L。女性ALT ULN随着年龄增大逐渐升高。男性各年龄组血清ALT均高于女性，差异均有统计学意义( t＝29.55、26.91、13.43、4.62，均 P<0.05)。 结论:血清ALT与性别和年龄有关，宁波地区健康成年男性血清ALT ULN为35 U/L，女性为26 U/L。

abstractsObjective:To reevaluate the upper limit of normal (ULN) of serum alanine aminotransferase (ALT) by retrospectively analyzing the ALT levels in healthy people in Ningbo area.Methods:A total of 56 140 people who underwent health examination and detection of liver biochemical indexes in the Affiliated Hospital of Medical School of Ningbo University and Yinzhou Huamao Hospital of Ningbo from 2018 to 2020 were enrolled. After excluding relevant factors that may lead to liver injury, 11 411 people were included to compare the difference of serum ALT levels among different genders and age groups (20 to 29 years, 30 to 39 years, 40 to 49 years and 50 to 59 years) to determine the ALT ULN in different gender groups. Statistical methods were performed using two independent samples t test and analysis of variance. Results:The serum ALT of males was (19.20±7.90) U/L, which was higher than that of females ((13.75±6.17) U/L), with statistical significance ( t=41.16, P<0.001). The serum ALT ULN in males and in females were 35 U/L and 26 U/L, respectively. The serum ALT levels of 20 to 29, 30 to 39, 40 to 49 and 50 to 59 years old groups were (15.48±7.61) U/L, (16.21±7.40) U/L, (17.36±7.52) U/L and (18.77±7.57) U/L, respectively.The difference was statistically significant ( F=71.51, P<0.001). Serum ALT level in 50 to 59 years old group was higher than that in 20 to 29 years old group, and the difference was statistically significant ( t=13.11, P<0.01). In males, the ALT ULN of 20 to 29 years old was the lowest of 34.43 U/L, and highest of 35.29 U/L in 40 to 49 years old. In females, the ALT ULN in the 20 to 29 years old group was the lowest of 23.01 U/L, and the ALT ULN in the 50 to 59 years old group was the highest of 30.79 U/L. ALT ULN increased with age in females. The serum ALT of males was higher than that of females in all age groups ( t=29.55, 26.91, 13.43 and 4.62, respectively, all P<0.05). Conclusions:The serum ALT level is significantly correlated to gender and age. The serum ALT ULNs of healthy adult are 35 U/L in males and 26 U/L in females in Ningbo area.