摘要目的 探讨超声造影引导下联合止血剂注射治疗肾挫裂伤的可行性.方法 18只新西兰大白兔开腹建立Ⅲ～Ⅳ级模拟钝性挫裂伤,随机数字表法分成三组:在超声造影引导下分别注射血凝酶(A组)、血凝酶联合α-氰基丙烯酸酯止血(B组)和等渗盐水(C组),观察止血时间、止血效果、肾周血肿等情况.结果 治疗后1 h,A、B、C组的肾周积液宽度分别为(0.200±0.012)cm,(0.050±0.002)cm和(0.400±0.009)cm,A、B组与C组比较,差异有统计学意义(P＜0.05).治疗后7,14 d复查,A组病灶长径分别为(1.107±0.143)cm和(0.433±0.163)cm,B组分别为(0.567±0.082)cm和(0.160±0.078)cm,C组分别为(0.980±0.203)cm和(0.686±0.157)cm,治疗后14 d,A、B组与C组间比较,差异有统计学意义(P＜0.01).A组病灶较B组大(P＜0.01).但B组治疗1个月后出现轻度肾积水的情况.结论 单纯注射血凝酶与联合注射血凝酶和α-氰基丙烯酸酯均能够达到止血效果,但后者的止血效果更加迅速、可靠.

abstractsObjective To study feasibility of combined haemostatic percutaneous injection therapy guided by contrast-enhanced ultrasonography (CEUS) in treatment of renal injuries. Methods Eighteen New Zealand rabbits were inflicted with kidney injury imitating grades Ⅲ-Ⅳ blunt injuries. The animals were randomly and equally divided into three groups, Group A ( treated with hemocoagulase),Group B ( treated with hemocoagulase and Alpha-cyanoacrylate) and Group C ( control group, given normal saline). The hemostatic time, hemostatic effect, and perirenal hematoma were observed. Results A perirenal hematoma was observed one hour after treatment. The perirenal fluid thickness was (0.200 ±0.012) cm in Group A, (0.050 ±0.002) cm in Group B and (0.400 ±0.009) cm in Group C, with statistical significance between two test groups and Group C (P ＜ 0.05 ). At days 7 and 14 following treatment, lesion length and cross section was ( 1. 107 ±0. 143) cm and (0.433 ±0. 163) cm in Group A, (0.567 ±0.082) cm and (0. 160 ±0. 078) cm in Group B, and (0.980 ±0. 203) cm and (0.686 ± 0. 157) cm in Group C. There was statistical significance between the test groups (Groups A and B) and Group C (P＜0. 01) at day 14. The lesion size in Group A was lager than that in Group B (P ＜ 0.01 ). One month after treatment, a slight nephrohydrosis occurred in Group B. Conclusions Either injection of simple hemocoagulase or combined use of hemocoagulase and Alpha-cyanoacrylate guided by CEUS can attain positive hemostatic effect, but the latter one is more rapid and reliable.