摘要本文对36只冠脉临界狭窄的杂种犬施行了定量潘生丁负荷超声心动图试验（DSET）。动物分为3组：小剂量（潘生丁0.5mg/kg/4min，静注），大剂量组（潘生丁1.0mg/8min，静注）。和对照组（生理盐水10ml/4min，静注用药前、后连续记示两维超声心动图（2DE），平均主动脉压（MAP）、心率（HR）、左室舒张末期压（LVEDP）、远端冠脉压（DCP）和节段性冠脉阻力（SCR），并同时观察ECG。结果显示：大剂量潘生丁注射后，MAP从13.4±0.8下降到10.6±1.0kPa（ P<0.05）；HR略有减低（ P<0.05），DCP明显减少（下降30~35%），CBF减少超过40%，2DE可检出局部室壁运动异常（RWMA）；而在小剂量组，DCP仅下降10~20%，CBF增加10~20%，而HR无明显变化（ P>0.05）。结论：冠脉临界狭窄时，由于CBF和SCR对定量潘生丁试验呈双向变化，所以，小剂量潘生丁不能诱发明显的RWMA，而大剂量潘生丁注射后，2DE即可检出明显的一过性心肌缺血。

abstractsThe quantitative dipyridamole stress echocardiography test (DSET) was performed in 36 mongrel dogs with critical coronary stenosis. The dogs were separated into 3 groups according to the dose of diphyridamole: group of small dose dipyridamole (0.5mg/kg/4min, i. v), group of high dose dipyridamole (1.0mg/kg/8min, i. v) and control (saline, 10ml/4min, i. v). Two dimensional echocardiography (2DE) was monitored during dipyridamole infusion and mean aortic pressure (MAP), heart rate (HR), left ventricular end-diastolic pressure (LVEDP), distal coronary pressure (DCP), segmental coronary resistance (SCR) and ECG were recorded simultaneously before and after dipyridamole infusion. Results showed that during the infusion of dipyridamole, the MAP fell from 13.4±0.8 to 10.6±1.0kPa ( P<0.05); HR decreased from 146±8 to 129±11 veats/min ( P<0.05), DCP decreased by 30~35%, CBF decrreased by>40% and RWMA was detected by 2DE in the group with high dose of dipyridamole; but the DCP decreased by 10~20%, CBF increased to 10~20% and HR were unchanged ( P>0.05) in the group with small dose of dipyridumole. Conclusion: because there were dual responses of CBF and SCR of critical coronary artery stenosis quantitative of dipyridamole stress test, the RWMA was not induced by 2DE in small dose of dipuridamole but transient myocardial ischemia was significantly detected by 2DE in high dose of dipyridamole.