摘要目的 探讨慢性子宫内缺氧对子代雄性兔成年期腹主动脉内-中膜厚度(IMT)和应变率的影响.方法 新西兰孕兔16只,分为慢性子官内缺氧和非慢性子宫内缺氧2组,待分娩后去除雌性,再随机取每只母兔的雄性子代2只,母乳饲养3个月后,慢性子宫内缺氧和非慢性子宫内缺氧组子代兔均再分高脂和正常饮食,即得慢性子宫内缺氧并高脂饮食组、非慢性子宫内缺氧并高脂饮食组、慢性子宫内缺氧并正常饮食组和非慢性子宫内缺氧并正常饮食组即正常对照组,每组各8只.至出生后6个月末测量血脂及腹主动脉IMT和应变率.结果 慢性子宫内缺氧可引起子代雄性兔成年期血清总胆同醇、甘油三酯增高(P<0.01),导致腹主动脉中内膜发生一系列病理改变,IMT增厚(P<0.05),应变率降低(P<0.05).慢性子宫内缺氧与高脂血症能协同加重上述观察指标变化(P<0.05或P<0.01).结论 慢性子宫内缺氧引起子代雄性兔成年期腹主动脉IMT增厚和应变率降低.

abstractsObjective To investigate the the effects of chronic intrauterine hypoxia on intimal-media thickening(IMT) and strain rate(SR) in abdominal aorta of male offspring rabbits during adult age.Methods Sixten New-Zealand rabbits were assigned randomly to 2 groups: chronic intrauterine hypoxia group (CIH, 12% O_2, n = 8) and normal oxygen group (NO,21%O_2, n = 8).After delivery,2 male offspring rabbits per litter were selected and breast-fed for 3 months, randomly divided into high-fat diet and normal diet groups.Finally, there were 4 groups in this experiment:chronic intrauterine hypoxia with high fat diet (CIH + HFD, n = 8) ,non-chronic intrauterine hypoxia with high fat diet (NCIH + HFD, n = 8),chronic intrauterine hypoxia with normal diet (CIH + ND, n = 8) and normal control (NC, n = 8).At sixth months of age, Serum levels of total cholesterol(TC) and triglyceride(TG) were assayed.SR in the abdominal aorta of male offspring rabbits was evaluated by ultrasonography.Then, abdominal aorta was taken out and observed by electron microscope and IMT was measured.Results CIH increased the levels of TC and TG (P < 0.01), thickened the IMT (P<0.05) and decreased the SR(P<0.05) of abdominal aorta of male offspring rabbits during adult age.There were relevant pathological changes in different groups.All these above-mentioned profiles were aggravated significantly after feeding high fat diet (P<0.05 or P<0.01).Conclusions CIH increased the IMT and decreased the SR of abdominal aorta of male offspring rabbits during adult age.