摘要目的 探讨双胎输血综合征(TTTS)胎儿产尿率(UPR)比值的临床价值.方法 8例TTTS胎儿为病例组,选择同期进行连续性超声检查的22例单绒毛膜双羊膜腔(MCDA)双胎作为正常对照组.采用三维超声计算机辅助虚拟脏器分析(VOCAL)测量两组胎儿UPR并计算双胎间UPR比值.结果 ①不同孕周正常MCDA双胎UPR比值较恒定,为0.97±0.28；胎儿UPR比值与孕周的相关系数为0.13,UPR比值与孕周无明显相关性.②与正常MCDA双胎比较,TTTS胎儿UPR受/UPR供比值明显增高(7.83±2.61,t=6.19,P＜0.05).结论 胎儿UPR比值是评估TTTS胎儿的一项重要指标.

abstractsObjective To evaluate the clinical value of the rate of fetal urine production rate (UPR) in fetus with twin-to-twin transfusion syndrome(TTTS).Methods 22 continuative normal monochorionic diamniotic(MCDA) twin fetuses were selected as controll group.Eight fetuses with TTTS were selected as disease group,and UPR was measured by three-dimensional ultrasound virtual organ computer-aided analysis (VOCAL) and the rate of UPR in twin was calculated.Results 1)The rate of UPR of twin fetuses in MCDA did not vary significantly throughout pregnancy (0.97 ± 0.28).The correlation coefficient between the rate of UPR and gestational age was 0.13,without obvious correlation.2)The rate of UPR-recipient/UPR-donor in TTTS fetuses increased significantly compared with MCDA twin fetus (7.83 ± 2.61,t =6.19,P ＜0.05).Conclusions The rate of UPR may be an important index in the assessment of TTTS.