剪切波弹性成像定量测量活体血栓弹性的实验研究
Quantitative evaluation of the thrombosis elasticity in vivo by shear wave elastography
摘要目的:探讨剪切波弹性成像对不同时期深静脉血栓的诊断价值。方法建立兔深静脉血栓动物模型,应用无创的剪切波弹性成像技术分别测量1、4、7、10、14 d 的血栓杨氏模量值。结果血栓的弹性模量值随时间的延长而增长,从第1 d 的(4.00±1.42)kPa 增长到第14 d 的(25.71±6.09)kPa,不同时间点的杨氏模量比较差异具有统计学意义(P <0.05)。结论剪切波弹性成像能有效地反映不同时期血栓的弹性硬度,可以根据血栓的弹性硬度初步判断血栓的时期。
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abstractsObjective To evaluate the diagnostic value of shear wave elastography on deep venous thrombosis in different stage.Methods Models of rabbits'deep venous thrombosis have been established to noninvasively measure Young's moduli of thrombosis in day 1 ,4,7,10 and 14 respectively by shear wave elastography.Results The elastic modulus of thrombosis increased with increment of the stages of thrombosis.Specifically,the mean Young's moduli of thrombosis increased from (4.0±1 .42)kPa (day 1)to (25.71 ±6.09)kPa (day 14),with statistical differences between each two observation time points (P <0.05).Conclusions Shear wave elastography can effectively reflect the elasticity of thrombosis in different stages,and the stage of thrombosis can be estimated judging by quantitative ultrasound elasticity preliminarily.
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