摘要目的 探讨利用超声弹性成像信息构建前列腺个性化生物力学模型以指导经直肠三维超声与磁共振图像配准的临床价值.方法 2016年6-12月于中山大学附属第一医院欲行手术治疗的5例前列腺疾病患者及1个标准前列腺体模纳入本研究,分别对其行经直肠超声弹性成像、经直肠三维超声成像 (three-dimensional transrectal ultrasound,3D-TRUS)以及磁共振成 像 (magnetic resonance imaging,MRI)扫描检查.利用患者的弹性成像信息对其前列腺进行个性化生物力学建模,并利用该模型指导磁共振图像与三维超声图像的配准.使用目标配准误差 (target registration error,TRE)对配准的结果进行评估,研究结合弹性信息的前列腺生物力学模型指导 MRI-TRUS配准的价值,并对配准结果进行统计学分析.结果 前列腺体模数据与5例患者数据均配准成功.前列腺体模的目标配准误差为1.65 mm.5例患者的平均目标配准误差为1.31 mm,相较于不使用弹性信息的配准误差 (2.52 mm)降低了48% (P <0.05).结论 利用超声弹性成像信息构建的前列腺个性化生物力学模型对指导磁共振图像与经直肠三维超声图像的配准具有实际的临床价值,有助于利用于超声引导的前列腺靶向穿刺.

abstractsObjective To evaluate the clinical significance of personalized biomechanical modeling of prostate deformation based on ultrasound elastography for magnetic resonance imaging(MRI)-transrectal ultrasound(TRUS)image registration.Methods A total number of 5 patients and 1 commercial prostate phantom were imaged via transrectal ultrasound elastography,3D-TRUS and MRI from June 2016 to December 2016.A personalized biomechanical model via the patient-specific ultrasound elastography was made for the deformable registration of prostate MRI and 3D-TRUS images.The registration accuracy was evaluated by the target registration error(TRE)and also the t-test was conducted to validate the statistical significance of our results.Results All the 5 sets of patient data as well as the phantom data were successfully registered.The TRE value of the phantom data was 1.65 mm.The mean TRE value of 5 patients was 1.31 mm,compared with the 2.52 mm TRE value of the registration method without patient-specific biomechanical properties via elastography,was approximately 48% lower(P <0.05).Conclusions Personalized biomechanical modeling of prostate deformation based on ultrasound elastography for MRI-TRUS image registration possesses important clinical significance and is a promising way to provide more quality guidance and improve the accuracy of prostate biopsy.