摘要目的 比较超声造影(CEUS)和普美显磁共振(EOB-MRI)对肝硬化背景下直径≤2cm肝细胞肝癌(HCC)的诊断效能,探究CEUS动脉期联合EOB-MRI肝胆期对微小肝癌的诊断价值.方法 回顾性分析2016年2-12月于天津市第三中心医院收集的98例肝硬化患者共113个直径≤2cm的结节在CEUS和EOB-MRI中的增强模式.以病理诊断或随访作为参考标准,分析CEUS和EOB-MRI对直径≤2 cm HCC的诊断效能.以CEUS动脉期联合EOB-MRI肝胆期作为HCC的诊断标准,探究该诊断标准对直径≤2 cm HCC的诊断价值.结果 CEUS和EOB-MRI对HCC单独诊断的ROC曲线下面积分别为0.858、0.814 (P ＞0.05),敏感性为79.1％、81.4％,特异性为92.6％、81.5％,准确性为82.3％、81.4％.以CEUS和EOB-MRI同时诊断HCC作为标准,ROC曲线下面积为0.831,与CEUS和EOB-MRI单独诊断相比差异无统计学意义(0.831对0.858,0.814;均P＞0.05),对HCC的诊断敏感性为66.3％,特异性为100％,准确性为74.3％.以CEUS动脉期高增强联合EOB-MRI肝胆期低信号作为诊断标准,ROC曲线下面积为0.934,与CEUS和EOB-MRI单独诊断及CEUS和EOB-MRI同时诊断相比差异有统计学意义(0.934对0.858,0.814,0.831;均P＜0.05),对HCC的诊断敏感性为94.2％,特异性为92.6％,准确性为93.8％.结论 CEUS动脉期联合EOB-MRI肝胆期对肝硬化背景下微小肝癌的诊断具有较高的敏感性和准确性,可作为在CEUS和EOB-MRI表现为不典型增强模式的微小HCC的新的补充增强模式,有助于HCC的诊断.

abstractsObjective To compare the diagnostic efficacies of contrast-enhanced ultrasonography (CEUS) and gadoxetic acid-enhanced magnetic resonance imaging (EOB-MRI) in the diagnosis of liver nodules ≤2.0 cm in patients with cirrhosis,and to explore the clinical values of combining the arterial phase of CEUS and hepatobiliary phase of EOB-MRI in the diagnosis of early hepatocellular carcinoma (HCC).Methods One hundred and thirteen nodules with diameters lower than 2.0 cm in 98 patients from February to December 2016 in Tianjin Third Central Hospital were included in this retrospective study.The enhancement patterns of nodules in CEUS and EOB-MRI were analyzed.The reference standard was pathological diagnosis or substantial lesion growth at a follow-up of at least 6 months.The efficiencies of CEUS and EOB-MRI in the diagnosis of liver lesions with a diameter lower than 2.0 cm were compared.A new diagnostic strategy,which combines the arterial phase of CEUS and hepatobiliary phase of EOB-MRI was presented to diagnose the early HCC in this study.Results The area under the ROC curve of CEUS and EOB-MRI were 0.858 and 0.814 (P ＞ 0.05),the sensitivity were 79.1％,81.4％,specificity were 92.6 ％,81.5 ％ and diagnostic accuracy were 82.3 ％ and 81.4 ％,respectively.By combination of CEUS and EOB-MRI,the area under the ROC curve was 0.831,without difference from CEUS,EOB-MRI (0.831 vs 0.858,0.814;all P ＞0.05);its sensitivity was 66.3 ％,specificity was 100％ and diagnostic accuracy was 74.3％.The area under the ROC curve of the new diagnostic strategy,combining the arterial phase of CEUS and hepatobiliary phase of EOB-MRI was 0.934,which was larger than that of CEUS,EOB-MRI and the combination of CEUS and EOB-MRI(0.934 vs 0.858,0.814,0.831;all P ＜0.05).The sensitivity,specificity and diagnostic accuracy of new strategy were 94.2％,92.6％ and 93.8％,respectively.Conclusions The new diagnostic strategy based on the arterial phase of CEUS and hepatobiliary phase of EOB-MRI improves the sensitivity and accuracy in detecting small lesions,which can be used as a complementary diagnostic enhancement pattern for lesions with an atypical enhancement pattern in CEUS or EOB-MRI.