摘要目的:应用四维自动左心房定量（4D Auto LAQ）技术评价非梗阻性肥厚型心肌病（NOHCM）合并心房颤动（以下简称房颤）患者的左心房结构和功能，并探讨左心房重构与房颤的相关性。方法:前瞻性选取2023年5月至2024年9月在郑州大学第一附属医院就诊的NOHCM患者90例，根据是否合并房颤分为房颤组27例和无房颤组63例。收集所有入选患者临床资料，测量二维、彩色多普勒、组织多普勒等超声参数，并应用4D Auto LAQ 技术获取左心房容积和应变参数。采用组间比较、单因素和多因素Logistic回归分析及重复性检验对数据进行分析。结果:与无房颤组的NOHCM患者相比，房颤组左心房最大容积指数（LAVImax）、左心房最小容积指数（LAVImin）、左心房收缩前容积指数（LAVIpreA）增大，左心房总射血分数（LAEF）、左心房被动射血分数（LApEF）、左心房主动射血分数（LAaEF）以及左心房储备期纵向及圆周应变（LASr、LASr-c）、左心房管道期纵向及圆周应变（LAScd、LAScd-c）和左心房收缩期纵向及圆周应变（LASct、LASct-c）的绝对值降低（均 P＜0.05）。多因素Logistic回归分析显示LAVImin与NOHCM患者房颤发生独立相关（ OR=0.837， P＜0.001）。 结论:4D Auto LAQ技术能够定量评价NOHCM合并房颤患者左心房结构和功能，且LAVImin与房颤存在独立相关。

abstractsObjective:To evaluate the left atrial structure and function in patients with non-obstructive hypertrophic cardiomyopathy（NOHCM）and atrial fibrillation（AF）using four-dimensional automatic left atrial quantification（4D Auto LAQ）technology，and to explore the correlation between left atrial remodeling and AF.Methods:Ninety patients with NOHCM treated in the First Affiliated Hospital of Zhengzhou University from May 2023 to September 2024 were prospectively selected and divided into AF group（ n=27）and non-AF group（ n=63）according to whether they had AF. Clinical data of all enrolled patients were collected，and two-dimensional，color Doppler，and tissue Doppler ultrasound parameters were measured. 4D Auto LAQ technology was used to obtain left atrial volume and strain parameters. Inter-group comparison，univariate and multivariate Logistic regression analysis，and repeatability test were used to analyze the data. Results:Compared with non-AF group，left atrial maximum volume index（LAVImax），left atrial minimum volume index（LAVImin）and left atrial pre-systolic volume index（LAVIpreA）were increased in the AF group，but left atrial total ejection fraction（LAEF），left atrial passive ejection fraction（LApEF），left atrial active ejection fraction（LAaEF）and the absolute values of left atrial reservoir longitudinal and circumferential strains（LASr，LASr-c），left atrial conduit longitudinal and circumferential strains（LAScd，LAScd-c）and left atrial contraction longitudinal and circumferential strains（LASct，LASct-c）were decreased（all P<0.05）. Multivariate Logistic regression analysis showed that LAVImin was independently associated with AF（ OR=0.837， P<0.001）. Conclusions:4D Auto LAQ can quantitatively evaluate the left atrial structure and function in patients with NOHCM and AF，and LAVImin is independently associated with the presence of AF.