Upregulated gene expression of local brain-derived neurotrophic factor and nerve growth factor after intracisternal administration of marrow stromal cells in rats with traumatic brain injury

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摘要Objective: To examine the effects of rat marrow stromal cells (rMSCs) on gene expression of local brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) after injection of rMSCs into Cistern Magnum of adult rats subjected to traumatic brain injury(TBI).Results: Group cell transplantation had higher BDNF and NGF gene expressions than Group saline control during a period of less than 3 weeks (P<0.05).Conclusions: rMSCs transplantation via Cistern Magnum in rats subjected to traumatic brain injury can enhance expressions of local brain NGF and BDNF to a certain extent.

作者 胡德志 ^[1] 周良辅 ^[1] 朱剑虹 ^[2] 毛颖 ^[1] 吴雪海 ^[1] 学术成果认领

作者单位 Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China ^[1] Department of Genetics, Harvard Medical School, 320 Longwood Avenue Enders BLDG 850, Boston, MA 02115 ^[2]

关键词 Marrow stromal cells Brain injuries Reverse-transcription polymerase chain Brain-derived neurotrophic factor Nerve growth factor

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ORIGINAL ARTICLES

发布时间 2005-03-17

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