摘要目的 研制鼻阻塞症状评估量表(NOSE)中文版.方法 遵照国际规范程序引进量表,经正、逆向翻译,专家小组综合讨论,预试及初步考核满意后,选择鼻中隔偏曲患者223例和健康对照组80名进一步测试性能,接受临床检验,并与英文源量表及其他语言版本量表比较.采用SPSS 19.0软件进行数据分析.结果 中文版NOSE量表各项性能考核结果均达到或接近检验水准,与英文源量表性能相当.①可行性:试验组和对照组量表的接收率分别为97.6％和94.1％;平均完成时间分别为(1.5±0.5)、(1.0 ±0.5)min.②信度:克朗巴赫系数α=0.869,重测信度Spearman秩相关系数rs =0.996.③效度:量表得到专家认可;与医学结局研究短表-36(medical outcomes study short form-36,SF-36)和视觉模拟量表(visual analogue scale,VAS)的相关系数分别为-0.837和0.725;量表结构与源量表设计结构吻合.④反应度:术后3个月评分的标准化反应均数与效应量分别为1.34和1.21.⑤灵敏度:Mann-Whitney U检验显示量表能有效区分试验组(秩均值117.81)和对照组(秩均值43.19)生存质量,差异有统计学意义(P值均＜0.01).临床检验表明NOSE评分与鼻阻力参数具有相关性.结论 中文版NOSE量表考核结果满意,可作为评估鼻阻塞症状的工具.

abstractsObjective To develop the Chinese version of the nasal obstruction symptom evaluation (NOSE) questionnaire.Methods After introduction,forward and backward translation,synthesis,expert committee review,pretest,adaptation and validation followed the international guidelines,the Chinese version of NOSE scale was tested among 223 nasal septal deviation patients and 80 health volunteers to further assess its psychometric and clinical properties.SPSS 19.0 software was used to analyze the data.Results The Chinese version demonstrated satisfactory evaluation results.The acceptance rate of the questionnaire was 97.6％ and 94.1％ in the patient group and control group respectively,and the completion time was (1.5 ± 0.5) min and (1.0 ± 0.5) min.Internal consistency reliability (Cronbach' s α) was calculated to be 0.869.Test-retest reliability coefficient was adequate at rs =0.996.Content validity was approved by our expert committee.Criteria validity (Spearman correlation coefficient) between NOSE Chinese version and SF-36,as well as VAS was-0.837 and 0.725 separately.Construct validity of Chinese version was similar to that of the original edition.The standardized response mean and the effect size at three months postoperatively was respectively 1.34 and 1.21,indicating high responsiveness.Calculated by Mann-Whitney U test,the instrument showed excellent sensitivity to discriminate the subjects with or without nasal obstruction (P ＜ O.01).The NOSE scores were also correlated with nasal resistance by rhinomanometry.Conclusions The NOSE Chinese version was successfully cross-cultural adapted and validated.It therefore can be recommended as a robust tool for future measuring subjective severity of nasal obstruction in China.