摘要目的:评估高清智能染色内镜（iSCAN）结合频闪喉镜鉴别声带白斑病变的临床应用价值。方法:回顾性分析2020年10月至2021年8月于浙江大学医学院附属第二医院耳鼻咽喉科行CO 2激光喉显微手术明确病理性质的79例声带白斑患者资料，其中男性75例，女性4例，年龄33~90（61.5±10.3）岁。术前采用iSCAN和频闪喉镜观察和评估病变形态学特征、微血管形态、黏膜波特点等，并与病理检查结果进行相关性分析。采用SPSS 20.0软件进行统计学分析。 结果:79例患者，共119侧病变（56侧左，63侧右）。病理检查结果诊断为恶性病变（重度异型增生，原位癌及浸润癌）的声带侧别为51侧，良性病变为68侧。频闪喉镜下，黏膜波正常及轻度减退69侧，重度减退及消失50侧，黏膜波减退程度与恶性病变正相关（ ρ=0.687， P<0.001）。iSCAN内镜下，病变部位微血管形态变化（垂直）与恶性病变正相关（ ρ=0.687， P<0.001）。单因素分析结果显示，病灶大、厚、颜色不均匀、颗粒状隆起、周边红斑和不对称与恶性病变正相关（ ρ=0.530、0.401、0.538、0.315、0.497、0.281， P<0.05）。Logistic回归分析显示，病灶大的恶性病变风险是病灶小的5.437倍，iSCAN内镜下垂直血管改变的恶性病变风险是血管形态正常的8.711倍，黏膜波重度减退或消失恶性病变风险是黏膜波正常或轻度减退的9.12倍。 结论:iSCAN结合频闪喉镜，可以全面观察和评估声带白斑患者的声带形态、黏膜下微血管及声带黏膜波的变化，提高良恶性病变的鉴别能力。

abstractsObjective:To evaluate the clinical value of high-definition intelligent endoscopy (iSCAN) combined with stroboscopy in identifying vocal cord leukoplakia.Methods:Seventy-nine patients with vocal cord leukoplakia who underwent CO 2 laser laryngeal microsurgery and diagnosed by histopathology were recruited between October 2020 to August 2021. The morphological features, microvascular morphology and mucosal waves were observed by stroboscope; SPSS 20.0 software was used for statistical analysis. Results:There were 79 patients with a total of 119 lesions (56 on left and 63 on right).Pathological examination showed that 51 sides of the vocal cords were malignant lesions (severe dysplasia, carcinoma in situ and invasive carcinoma), and 68 sides were benign lesions.Under stroboscopy, 69 sides of mucosal wave were normal or slightly decreased, and 50 sides were severely decreased or disappeared.The decrease degree of mucosal wave was positively correlated with malignant lesions ( ρ=0.687, P<0.001).Under iSCAN endoscopy, there was a positive correlation between the morphological changes of microvessels at the lesion site (vertical) and the malignant lesion ( ρ=0.687, P<0.001).Univariate analysis showed that lesion size, thickness, uneven color, granular elevation, peripheral erythema and asymmetry were positively correlated with malignant lesions ( ρ=0.530, 0.401, 0.538, 0.315, 0.497, 0.281, P<0.05).Logistic regression analysis showed that the risk of pathological malignancy with large lesions was 5.437 times higher than those of small lesions, the vertical vascular changes under iSCAN were 8.711 times higher than that of normal vascular morphology, and the severe reduction or disappearance of mucosal waves was 9.12 times higher than that of normal or mild reduction of mucosal waves. Conclusion:ISCAN can be combined with staphyloscopy to comprehensively observe and evaluate the changes of vocal cord morphology, submucosal microvessels and mucosal wave of vocal cord in patients with vocal cord leukoplosis, thus improving the ability to distinguish benign and malignant lesions.