摘要目的:通过高密度聚乙烯植入物在成年人唇腭裂鼻畸形及功能异常相关手术中的使用，评估术后患者改善鼻外形及症状的临床效果。方法:回顾性研究2018年1月至2022年1月于上海交通大学医学院附属第九人民医院就诊的唇腭裂术后伴有鼻畸形的患者12例，其中男7例、女5例，年龄18~29岁。对所有患者进行鼻畸形矫正术，如有需要则同期行鼻中隔矫正术，术中应用高密度聚乙烯植入物（MEDPOR/Su-Por）。术后至少随访6个月，测量相关外形指标及主观视觉模拟量表（VAS）评分，比较手术前后的临床效果。采用SPSS 22.0统计软件进行相关分析。结果:与术前相比，患者术后的鼻塞VAS评分降低（4.83±0.94）分；外形满意度VAS评分提升（3.92±1.08）分；鼻小柱高度提高（1.79±0.78）mm；鼻尖高度提高（2.79±1.50）mm；患侧鼻孔高度提高（1.83±0.62）mm；患侧鼻底宽度缩小（0.42±0.47）mm，以上指标的术前术后差异均具有统计学意义（ P值均<0.05）。 结论:高密度聚乙烯植入物在唇腭裂鼻畸形及功能异常相关手术中能有效改善鼻部外形和功能，是一种较为理想的人工合成材料。

abstractsObjective:Through the use of high-density polyethylene implants in adults with cleft lip and palate nasal deformities and abnormal functions, to evaluate the clinical effect of postoperative patients on improving nasal shape and symptoms.Methods:A retrospective study of 12 patients with nasal deformities after cleft lip and palate surgery in the Shanghai Ninth People′s Hospital Affiliated to Shanghai JiaoTong University School of Medicine from January 2018 to January 2022 was completed, including 7 males and 5 females, with the age ranging from 18 to 29 years. All the patients underwent nasal deformity correction, and nasal septum correction was performed if necessary. High-density polyethylene implants (MEDPOR/Su-Por) were used intraoperatively. Follow-up for at least 6 months was performed to measure the relevant appearance indicators and subjective Visual Analog Scale (VAS) scores, and to compare the clinical effects before and after surgery. SPSS 22.0 software was used for statistical analysis.Results:Before and after surgery, the average VAS score of nasal obstruction decreased by (4.83±0.94) points; the average VAS score of appearance satisfaction increased by (3.92±1.08) points; the height of nasal columella was increased by (1.79±0.78)mm; the height of nasal tip was increased by (2.79±1.50)mm; the height of ipsilateral nostril was increased by (1.83±0.62)mm; the width of the ipsilateral nasal floor was reduced by (0.42±0.47)mm. All of above were statistically significant (all P<0.05). Conclusion:High-density polyethylene implants can effectively improve the shape and function of the nose in operations related to cleft lip and palate nasal deformity and abnormal functions, and are an ideal synthetic material.