摘要Objective:It remains unknown whether calcium metabolism has any effect on the clinical presentation of superior semicircular canal dehiscence(SSCD).Our aim was to analyse the adjusted calcium and vitamin D levels in SSCD patients compared to a control group.Methods:This was a prospective case-control study performed in a tertiary referral center,university teaching hospital in the UK.It included all new patients with SSCD seen in a dedicated skull base clinic over a 5-year period(2015-2019)compared to a gender and age matched control group.The main outcome of the study was adjusted calcium and Vitamin D levels between the two groups.Results:A total of 31 SSCD patients were recruited with a matched number of control patients.The mean Vitamin D level on the SSCD group was 44.8 nmoL/l(SD:20.8)compared to 47.5 nmoL/1(SD:27.4)on the control group(p = 0.702).Mean Adjusted calcium level was 2.34 mmoL/1(SD:0.7)for SSCD compared to 2.41 mmoL/l(SD:0.11)for controls(p = 0.01),being within normal limits for both the SSCD and the control group.Conclusion:Our study did not identify a link between Vitamin D levels and presence of SSCD.Normal adjusted calcium values were found in both groups.Despite that a statistically significant lower calcium level was found in the SSCD group which could indicate that suboptimal levels of calcium may affect the micro-environment of the otic capsule at the SSC region.