摘要Background:The masseter vestibular evoked myogenic potential(mVEMP)is a novel test that has been explored in various brainstem lesions.How-ever,it has not yet been studied in individuals with definite Meniere's disease.Therefore,the current study aimed to investigate mVEMP responses in individuals with definite Meniere's disease and compare them with those of a reference group.Method:The present study investigated narrowband Claus Elberling chirp-evoked mVEMP responses in 22 ears diagnosed with definite Meniere's disease and 22 ears with hearing sensitivity ≤ 15 dB HL across three stimulation frequencies.Results:mVEMP responses in participants with definite Meniere's disease varied from normal to reduced or absent across three octave frequencies.These individuals exhibited significantly reduced P11-N21 peak-to-peak amplitudes compared to those in the reference group.Although a frequency tuning shift toward 1000 Hz was observed,the inter-frequency amplitude ratio of mVEMP was not found to be a sensitive parameter for detecting individuals with definite Meniere's disease.Additionally,no association was found between the degree of hearing loss or the duration of the disease and mVEMP responses.Conclusion:Participants with definite Meniere's disease exhibited reduced P11-N21 amplitude and a tuning shift toward 1000 Hz.These findings suggest the involvement of the vestibulo-trigeminal reflex pathway in this condi-tion.