摘要目的 探讨系统性红斑狼疮(SLE)并发无菌性骨坏死的危险因素.方法 应用Meta分析方法 对国内外14篇关于SLE并发无菌性骨坏死危险因素的病例对照研究结果进行综合分析;运用Review Manager 4.2进行一致性检验及合并比值比(OR值)和95%可信区间(95%CI)的计算.结果 SLE合并无菌性骨坏死的危险因素的OR值及95%CI分别是:雷诺现象2.43(1.12～5.29),口腔溃疡2.33(1.11～4.88),肾脏受累1.76(1.27～2.44),血管炎4.65(1.62～13.33),高脂血症3.28(1.76～6.12),抗磷脂抗体2.06(0.84～5.06).结论 糖皮质激素是SLE患者发生无菌性骨坏死的重要因素,但不是唯一因素.雷诺现象、口腔溃疡、肾脏受累、血管炎、高脂血症是SLE并发无菌性骨坏死的主要危险因素.

abstractsObjective To investigate the major risk factors of aseptic necrosis of bone in patients with systemic lupus erythemattrsus (SLE),and thus provide evidence for decision-making on prevention.Methods Meta-analysis Was used to systemically evaluate the 14 case-control studies about the risk factors of aseptic necrosis of bone in patients with SLE.Review Manager 4.2 Was utilized to carry out homogeneity checking and calculate the pooled odds ratio (OR) with 95% confidence interval.Results The OR values of risk factor of AVN in patients with SLE and 95% CI were as follows:Raynaud's phenomenon 2.43(1.12～5.29):dental ulcer 2.33(1.11～4.88);renal involvement 1.76(1.27～2.44);vasculitis 4.65(1.62～13.33):hyperlipidemia 3.28(1.76～6.12);anti-phospholipid antibody(APL)2.06(0.84～5.06):hypocomplementemia 0.63(0.35～1.14).Conclusion Glucocorticosteroid is an important risk factor in inducing aseptic necrosis of bone in patients with SLE,but it is not the only factor.Raynaud's phenomenon,dental ulcer,renal involve-ment,vasculitis and hyperlipidemia are major risk factors of aseptic necrosis of bone in patients with SLE.