摘要目的 总结分析大动脉炎合并皮肤黏膜损害的临床特点.方法 回顾性分析我院2000-2012年住院的大动脉炎患者的临床资料；计量资料采用配对t检验.结果 本研究共纳入487例大动脉炎患者,其中合并皮肤黏膜损害者38例(7.8％),女性31例,男性7例,平均年龄(26±11)岁.31例发生皮肤黏膜损害时病情活动,其中3例以皮肤黏膜损害起病.大动脉炎临床分型以广泛型(20例,53％)、头臂动脉型(10例,26％)多见.皮肤黏膜损害以口腔溃疡(19例,50％)、结节性红斑(9例,24％)和皮下结节(6例,16％)多见.皮肤病理提示血管炎和肉芽肿.经过大剂量糖皮质激素联合免疫抑制剂治疗,皮肤黏膜损害痊愈21例(55％),显效7例(18.4％),好转4例(11％),不详6例.结论 大动脉炎除了大动脉受累,亦可出现多种皮肤黏膜病变,与大动脉炎病情活动密切相关,对糖皮质激素联合免疫抑制剂治疗的应答良好.

abstractsObjective To investigate the clinical features of cutaneous and mucosal manifestations in patients with Takayasu's arteritis (TA).Methods The clinical data of TA patients who were admitted into Peking Union Medical College Hospital from 2000 to 2012 were retrospectively reviewed.Resnlts Four hundred and eighty-seven TA patients were enrolled.Cutaneous and mucosal lesions were documented in 38 patients (31 female and 7 male).The mean age was (26±11) years old.The cutaneous and mucosal lesions occurred along with active disease in 31 patients,and before the onset of TA in 3 patients.The most common sub-types of TA were extensive type (53％) and head-arm-artery type (26％).Oral ulcer (50％),erythema nodosum (24％) and subcutaneous nodule (16％) were the most prevalent cutaneous and mucosa lesions.Biopsy specimens showed vasculitis and granulomatosis.Most patients (87％) were treated with corticosteroids and immuno-suppressive agents and improved clinically.Conclusion The cutaneous and mucosal lesions of TA are not uncommon,which suggest active disease in TA.The prognosis of cutaneous and mucosal lesions is generally good with aggressive treatment.