摘要目的 总结3 cm以下肺恶性局灶性磨玻璃结节(fGGO)与实性结节的MSCT征象,旨在发现恶性fGGO是否存在特异性征象.方法 回顾性分析病理证实的3 cm以下的105例实性肺癌和48例恶性fGGO的基本临床资料、病灶大小及MSCT征象(病灶形态、边缘形态、瘤肺界面、内部结构及邻近结构改变),用Fisher确切概率法、X~2检验及非参数Mann-Whitney U检验进行统计学分析.结果 实性结节的男女比例(60:45)高于fGGO组(18:30),男女发病率差异有统计学意义(X~2值5.09,P<0.05).实性结节圆形或类圆形、不规则形、毛刺、空泡征、支气管征走行正常的分别为101、4、60、12、0例;fGGO相应分别为38、10、19、25、7例(X~2值依次为11.48、4.07、29.70、22.38,P值均<0.05),差异有统计学意义.实性结节的边缘形态(分叶、尖角、棘状突起)、瘤肺界面(清楚光整、清楚毛糙、模糊)、内部结构(蜂窝征)、邻近结构(胸膜凹陷征、血管集束征)分别为85、0、33、5、100、0、0、59、35例;fGGO相应分别为42、1、15、3、45、0、2、32、16例(X~2值依次为1.00、2.20、0.00、0.15、4.43、1.50、0.00,P值均>0.05),2组结节之间差异均无统计学意义.结论 恶性fGGO与实性结节的病灶形态、边缘形态、瘤肺界面、内部结构及邻近结构的改变大多数表现一致,但fGGO中不规则形、空泡征和支气管走形自然的概率在一定程度上高于实性结节,毛刺征低于实性结节,这与肿瘤的病理类型及肿瘤的病理学基础存在一定的关系.

abstractsObjective To compare the MSCT findings of malignant focal pulmonary ground-glass opacity nodules (fGGO) and solid nodules of 3 cm or less, and try to find specific signs in fGGO. Methods Clinical data (sex ratio, age), size of lesion and MSCT findings (shape, margin, interface, internal characteristics, adjacent structure) of 105 cases pathologically confirmed to have solid lung cancers and 48 cases with fGGO less than 3 cm were retrospectively analyzed. Differences were analyzed by using the Fisher exact test or Mann-Whitney U test. Results The male and female ratio of solid lung cancer(60:45) were higher than that of fGGO (18:30, X~2 value 5.09, P<0.05). But no differences were found in age and size of lesion (P value 0.200,0.673). For solid lung cancer, the incidence of round shape (n=101), irregular (n=4), speculation (n=60), vacuole sign (n=12) and air bronchograms (n=0) were significantly different from those of fGGO (38, 10, 19,25 and 7, respectively), and the corresponding (X~2 values were 11.48,4.07,29.70 and 22.38 respectively, P<0.05). No differences were found in lobulation, cusp angle, spine-like process, well-defined, coarse, ill-defined interface, honey-combing, pleural indentation sign and blood vessel cluster sign (there are 85,0,33,5,100,0,0,59,35 cases for solid cancer, and 42,1,15,3,45,0,2,32,16 for fGGO (X~2 values 1.00,2.20, 0.00,0.15, 4.43,1.50, 0.00, P>0.05). Conclusions Malignant fGGO and solid lung cancer manifest mostly similar MSCT features. The frequency of irregular shape, vacuole sign and air bronchograms was higher in fGGO than in solid lung cancer to some degree, but speculation is more infrequent in fGGO, which may be attribute to thepathological type and basis of tumor.