摘要目的 测量不同年龄段听力正常儿童蜗神经的直径,同时探讨其与年龄的相关性.方法 收集正常听力儿童156名共312耳,分为13组,即≤6个月、～1岁、然后～12岁每间隔1岁为1组,每组儿童12名,男、女各6名.所有儿童均行内耳三维稳态进动快速成像(FIESTA)序列扫描.2名阅片者在3.0T MRI横断面及斜矢状面图像上分别测量蜗神经入耳蜗处、内听道中点及内听道底处蜗神经的直径,最后取平均值.2名阅片者测量结果行组内相关系数(ICC)检验,不同性别、侧别间蜗神经直径行独立样本和配对样本t检验;单因素方差分析评价不同测量点蜗神经直径的变化;不同年龄组间蜗神经正常值的变化采用多因素方差分析;Spearman相关分析用于比较蜗神经不同测量点的直径与年龄之间的相关性.结果 本组儿童内听道中点、内听道底处、入耳蜗处蜗神经的直径分别为(1.12±0.08)、(1.05±0.06)、(0.87±0.14)mm,3个测量点间蜗神经直径差异有统计学意义(F=527.57,P＜0.05).蜗神经的直径在性别、侧别间、年龄组间差异均无统计学意义(P值均＞0.05),儿童正常蜗神经直径与年龄无相关性.结论 听力正常的儿童蜗神经直径在内听道不同点直径不同,内听道中点最大,内听道底次之,入耳蜗处最小;且正常值不随年龄的变化而改变.

abstractsObjective To measure the diameter of cochlear nerve(CN) in normal hearing children with different ages,and evaluate the diameter variations with age.Methods A total of 156 normal-hearing children were assessed with 3D-FIESTA sequence scanning of the inner ear.All the subjects were divided into 13 groups according to age,witha group of ≤6 months,a group of ≤1 year,and 11 groups from one year to 12 years.Each group had 12 cases,including 6 boys and 6 girls.The diameter of CN was measured at the entrance of the cochlea,the middle of internal auditory canal(IAC) and the fundus of IAC respectively on the axial and oblique sagittal images of 3.0 T MRI by two independent observers.The average values measured by them were the final results.The intraclass correlation coefficient was used to determine the consistency between the two independent observers.The t test was used to access differencesin CN diameter by sex and sides.One-way analysis of variance(ANOVA) and two-way ANOVA were used for comparisons among different groups.Spearman correlation coefficient was applied to find a correlation between the CN diameter and age.Results The diameters of normal-hearing children's CN at the middle of the IAC,IAC fundus and the entrance of the cochlea were (1.12 ± 0.08),(1.05 ± 0.06),(0.87 ± 0.14) mm respectively,and there was significant difference among the three measuring points (F=527.57,P＜0.05).The diameters of the CN had no significant differenc (P＞0.05) in age-groups,gender and sides(P＞0.05),and there was no correlation between the diameters of normal children's CN and age.Conclusions The diameters of normal-hearing children's CN change with different points of the IAC,of which the maximum value is at the middle of the IAC,followed by the IAC fundus,and the entrance of the cochlea is at the minimum,more over the normal size doesn't change with age.