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摘要本研究采用DpH探剂标记法、荧光分光光度计测定细胞膜脂流动性做为诊断恶性肿瘤的标志。人胚肺细胞癌变取决于 238Puα粒子的照射剂量；在0.5Gy照射后人胚肺细胞开始发生癌变。癌变细胞的微粘度较正常人胚肺细胞低；微粘度低者，流动性则高，反之亦然。结果表明，人胚肺受0.5、1.0Gy照射后其流动性分别为16.335±0.017，38.254±0.257。其中受1.0Gy照后的流动性与正常人胚肺细胞比较，差异有非常显著性（ P<0.01）。胞膜脂微粘度与细胞数呈正相关线性关系。细胞癌变早期发生在细胞膜脂区。

abstractsThe membrane lipid fluidity of malignantly transformed human embryo cells following 238Pu α particle irradiation in vitro has been studied. The results indicate that the oncogenesis depends on irradiation dose (Gy) and the membrane lipid fluidity in malignantly transformed cells is higher than that in normal embryo cells. With the micro viscosity (η) of cells plotted against the cell counts, the correlation coefficient (γ) is calculated to be between 0.9936 and 0.9999. Since the malignant transformation of irradiated embryo cells is manifested early on cell membrane lipid, the fluidity of membrane lipid can be used as an oncologic marker.