摘要目的 评价后装逆向调强放疗技术在妇科肿瘤治疗中的临床价值.方法 选取20例Ⅰ ～Ⅲ期宫颈癌患者,采用随机数字表和余数分组的方法分为A、B两组,各10例.A组病例行后装逆向调强放疗,B组病例行三维适形后装放疗.分析两组患者的靶区剂量分布、危及器官受量、放疗并发症及近期疗效.结果 A组靶区剂量均匀度指数(HI)为52.43±0.45,好于B组的46.37±1.45(t =0.92,P ＜0.05);A组直肠、膀胱最大受量Dmax分别比B组低37％、35％(t =1.34、1.39,P＜0.05),A组75％处方剂量的直肠、膀胱受照体积V75约为B组的1/2(t =1.23、1.13,P＜0.05);A组局部控制率96％好于B组的93％(t=1.25,P＜0.05).结论 后装逆向调强放疗优于三维适形后装放疗,值得在妇科肿瘤治疗中广泛应用.

abstractsObjective To evaluate the clinical value of the afterloading brachytherapy inverse intensity-modulated radiotherapy of gynecological tumor.Methods Twenty patients with cervical cancer,were randomly divided into A and B groups,10 cases for each group.Group A received the afterloading brachytherapy inverse intensity-modulated radiotherapy.Group B received the three-dimensional comformal afterloading brachytherapy.The target volume dose distribution,organs at risk (rectum,bladder),shortterm curative effect and radioactive complications were analyzed on both groups.Results The dose homogeneity index of the target volume of group A was 52.43-± 0.45,better than that of group B (46.37 ± 1.45) (t =0.92,P ＜ 0.05).The maximum dose of rectum and bladder of group A were about 37％,35％,less than that of group B (t =1.34,1.39,P ＜ 0.05).The 75％ prescription dose irradiated volume of rectum and bladder of group A were about only 1/2 of group B (t =1.23,1.13,P ＜ 0.05).The local control rate of 96％ for group A was better than 93％ for group B (t =1.25,P ＜ 0.05).Conclusions Afterloading brachytherapy inverse intensity-modulated radiotherapy technique could be better than the three-dimensional comformal afterloading brachytherapy.It should be recommended for gynecological tumor.