摘要目的 系统评价保乳术后放疗对三阴乳腺癌患者生存的影响.方法 计算机检索PubMed、Ovid、CBM、VIP、CNKI数据库,手工检索《中国乳腺病杂志》、《中国肿瘤临床》、《中华放射肿瘤学杂志》、《癌症》、《中华肿瘤杂志》、《实用肿瘤杂志》、《肿瘤》杂志.两位研究者独立对符合纳入标准资料进行回顾性队列研究,并用Reman5.1软件进行荟萃分析,以5年无远处转移率、总生存率和无局部复发率作为主要研究终点.结果 共5个研究2345例患者入组,其中三阴组417例、非三阴组1928例.三阴组5年无远处转移率、总生存率均低于非三阴组(Z =5.29、3.35,P=0.000、0.001),5年无局部复发率两组相似(Z=1.35,P=0.180).结论 三阴乳腺癌保乳术后放疗对局部控制有较好疗效.

abstractsObjective To systematically evaluate the influence of radiotherapy on triple-negative breast cancer (TNBC) patients treated with breast conservation surgery.Methods Electronic databases including PubMed,Ovid,CBM,VIP and CNKI and seven journals in Chinese (including the Chin J Breast Cancer,Chin J Clin Oncol,Chin J Radiat Oncol,Chin J Cancer,Chin J Oncol,J Pract Oncol and Tumor)were searched.Clinical trials comparing survival rates of patients with TNBC and non TNBC treated with breast conservation surgery and radiotherapy were reviewed.The quality assessment and data extraction were performed by two reviewers independently.RevMan5.1 software developed by the Cochrane collaboration was used for Meta-analysis.The 5-year distant metastasis-free survival (DMFS),overall survival (OS) and local recurrence-free survival (LRFS) rates were the primary end points.Results Five trials including 2345 patients with breast cancer were included in this systematic review.417 patients had TNBC and 1928 patients had non TNBC.Meta-analysis showed that the 5-year DMFS and OS rates of patients with TNBC were lower compared with non TNBC (Z =5.29,P =0.000 and Z =3.35,P =0.001).There was no statistical significant difference in 5-year LRFS rate between patients with TNBC and non TNBC (Z =1.35,P =0.180).Conclusion Radiotherapy provides good local control for patients with TNBC after breast conservation surgery.