摘要目的 观察食管癌术后辅助性放化疗患者不良反应发生情况及其与临床因素的关系.方法 对2014年49例接受了术后辅助性放化疗的食管癌患者出现RG、RP及骨髓抑制情况进行Logistic法因素分析.结果 全组患者出现2级RG 19例(39％),2级RP 7例(14％),2级骨髓抑制8例(16％).单因素分析结果显示与2级RG发生相关因素为胃长度大小(P=0.016);与2级RP发生相关因素为性别(P=0.026)和胃体积大小(P=0.047);与2级骨髓抑制发生相关因素为是否接受了≥2个周期化疗(P=0.000).多因素分析结果显示胃长度大小为2级RG独立影响因素(P=0.038);胃体积大小为2级RP独立影响因素(P=0.013).结论 术后胸腔胃状态影响着食管癌术后患者不良反应的发生情况,胃长度越长可能会增加2级RG的发生率,胃体积越大可能会增加2级RP的发生率.

abstractsObjective To investigate the incidence of adverse reactions in patients treated with postoperative adjuvant radiochemotherapy for esophageal carcinoma and its relationship with clinical factors.Methods Logistic regression was used for variate analyses on the incidence of radiation gastritis (RG),radiation pneumonia (RP),and marrow suppression in 49 patients with esophageal cancer who received postoperative adjuvant radiochemotherapy in 2014.Results In all the patients,19 (39％) patients had grade 2 RG,7 (14％) patients grade 2 RP,and 8 (16％) patients grade 2 marrow suppression.The univariate analysis showed that the length of stomach was associated with the incidence of grade 2 RG (P=0.016);sex and the volume of stomach were associated with the incidence of grade 2 RP (P=0.026;P =0.047);≥ 2 cycles of chemotherapy were associated with the incidence of grade 2 marrow suppression (P =0.000).The multivariate analysis showed that the length of stomach was an independent factor for grade 2 RG (P=0.038) and the volume of stomach was an independent factor for grade 2 RP (P=0.013).Conclusions The postoperative state of the intrathoracic stomach affects the incidence of adverse reactions in patients with esophageal carcinoma.A longer stomach may cause higher incidence of grade 2 RG and a larger stomach may cause higher incidence of grade 2 RP.